This Article Abstract Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Leineweber, K. Articles by Heusch, G. Search for Related Content PubMed PubMed Citation Articles by Leineweber, K. Articles by Heusch, G.

Intense Vasoconstriction in Response to Aspirate From Stented Saphenous Vein Aortocoronary Bypass Grafts

Kirsten Leineweber, PhD^_*, Dirk Böse, MD, Magdalene Vogelsang, MSc^_*, Michael Haude, MD, FACC, Raimund Erbel, MD, FACC and Gerd Heusch, MD, FACC^_*,_*

^_* Institute of Pathophysiology
Department of Cardiology, University of Essen School of Medicine, Essen, Germany

View larger version (20K): [in a new window]   Figure 1 Vasoconstrictor action of venous blood (VB, open circles/closed circles) and aspirate plasma (AS, open squares/closed squares) on rat mesenteric arteries with intact (open symbols = +E) and denuded endothelium (filled symbols = –E). Values are mean ± SEM of 14 patients. *p < 0.05 vs. AS–E; #p < 0.05 vs. VB+E, p < 0.05 with Bonferroni correction for six comparisons.

View larger version (12K): [in a new window]   Figure 2 Vasoconstrictor action of arterial blood (AB, open triangles/closed triangles) taken distal to the lesion and aspirate plasma (AS, open squares/closed squares) on rat mesenteric arteries with intact (open symbols = +E) and denuded endothelium (filled symbols = –E). Values are mean ± SEM of five patients. *p < 0.05 vs. AS–E; #p < 0.05 vs. AS+E with Bonferroni correction for six comparisons.

View larger version (15K): [in a new window]   Figure 3 Vasoconstrictor action of aspirate plasma in the absence (open squares/closed squares AS+/–E) and in the presence of 1 µmol/l ketanserin (5-HT2A/2C-receptor blocker) and 0.1 µmol/l pindolol (ß-adrenoceptor and 5-HT1A/1B-receptor blocker) (open diamonds/closed diamonds AS+/–E with 5-HT-R blockade) or in the presence of 1 µmol/l ketanserin, 0.1 µmol/l pindolol, and 10 µmol/l ICI 185,282 (thromboxane A2 TP-receptor blocker) (open inverted triangles/closed inverted triangles AS+/–E with 5-HT and TP-R blockade) on rat mesenteric arteries with intact (open symbols = +E) and denuded endothelium (filled symbols = –E). Values are mean ± SEM of 14 patients. *p < 0.05 vs. AS–E; #p < 0.05 vs. AS+E with Bonferroni correction for 15 comparisons.