The Relationship Between Plasma Levels of Oxidized and Reduced Thiols and Early Atherosclerosis in Healthy Adults
Salman Ashfaq, MD, FACC*,
Jerome L. Abramson, PhD ,
Dean P. Jones, PhD ,
Steven D. Rhodes, RN,
William S. Weintraub, MD, FACC,
W. Craig Hooper, PhD ,
Viola Vaccarino, MD, PhD,
David G. Harrison, MD, FACC and
Arshed A. Quyyumi, MD, FACC,*
* Division of Cardiology, University of Kansas School of Medicine, Wichita, Kansas
Division of Cardiology
Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia
Centers for Disease Control and Prevention, Atlanta, Georgia
View larger version (24K):
[in a new window]
|
Figure 1 Pearson correlations between the markers of oxidative stress and high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (IMT). (Top row, right) Eh GSH/GSSG; left: GSH; (bottom row, left) CySS; right: hs-CRP. CySS = cystine; Eh GSH/GSSG = glutathione redox state.
|
|
View larger version (15K):
[in a new window]
|
Figure 2 Relationship between Eh GSH/GSSG tertiles and carotid IMT: unadjusted relationship between carotid IMT (mean ± SEM) and Eh GSH/GSSG tertiles (p = 0.005 for trend, and p = 0.004 highest vs. lowest EhGSH/GSSG tertiles, n = 38 in each group). Abbreviations as in Figure 1.
|
|
View larger version (18K):
[in a new window]
|
Figure 3 Combined predictive value of Framingham risk score and Eh GSH/GSSG: subjects with higher levels of both oxidative stress and Framingham risk score had higher IMT (mean ± SEM) compared to subjects with lower levels of both markers (p < 0.001 highest vs. lowest group and p = 0.01 for trend). Abbreviations as in Figure 1.
|
|
|
