Rapid Induction of Cerebral Hypothermia Is Enhanced With Active Compression-Decompression Plus Inspiratory Impedance Threshold Device Cardiopulmonary Resusitation in a Porcine Model of Cardiac Arrest
Vijay Srinivasan, MD*,
Vinay M. Nadkarni, MD, MS*,*,
Demetris Yannopoulos, MD ,
Bradley S. Marino, MD, MSCE, MPP*,
Gardar Sigurdsson, MD,
Scott H. McKnite, BS,
Maureen Zook, BA,
David G. Benditt, MD and
Keith G. Lurie, MD
* Department of Anesthesia and Critical Care Medicine, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Hennepin County Medical Center and the Cardiac Arrhythmia Center, Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota
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Figure 1 Active compression-decompression (ACD) cardiopulmonary resuscitation (CPR) with impedance threshold device (ITD).
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Figure 2 Timeline of experimental protocol. ACLS = advanced cardiac life support; CPR = cardiopulmonary resuscitation; ROSC = return of spontaneous circulation.
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Figure 3 Comparison of brain temperatures for active compression-decompression plus an inspiratory impedance threshold device cardiopulmonary resusitation (ACD-ITD CPR) versus standard cardiopulmonary resuscitation (S-CPR) groups. ROSC = return of spontaneous circulation.
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Figure 4 Comparison of brain and arterial blood temperature curves between active compression-decompression plus impedance threshold device cardiopulmonary resuscitation (ACD-ITD CPR) and standard cardiopulmonary resuscitation (S-CPR). (A) Brain and arterial temperatures in ACD-ITD CPR. (B) Brain and arterial temperatures in S-CPR.
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