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Caffeine Decreases Exercise-Induced Myocardial Flow Reserve

Mehdi Namdar, MD^_*, Pascal Koepfli, MD^_*, Renate Grathwohl, MD^_*, Patrick T. Siegrist, MD^_*, Michael Klainguti, MD^_*, Tiziano Schepis, MD^_*, Raphael Delaloye, MD^_*, Christophe A. Wyss, MD^_*, Samuel P. Fleischmann, MD^_*, Oliver Gaemperli, MD^_* and Philipp A. Kaufmann, MD^_*,,_*

^_* Cardiovascular Center, Nuclear Cardiology, University Hospital
Center for Integrative Human Physiology (CIHP), University of Zurich, Zurich, Switzerland

View larger version (11K): [in a new window]   Figure 1 Individual values for myocardial blood flow (MBF) at rest and after exercise before and after caffeine consumption.

View larger version (11K): [in a new window]   Figure 2 Changes in myocardial blood flow (MBF) induced by caffeine. After caffeine consumption, resting MBF increased at hypoxia but not at normoxia, whereas exercise-induced hyperemic flow response was decreased in both groups. Caffeine blunted the hyperemic flow significantly more pronounced at altitude than at normoxia. Open bars = normoxia; solid bars = hypoxia. *p < 0.05 vs. baseline.

View larger version (15K): [in a new window]   Figure 3 Individual myocardial flow reserve (MFR) values before and after caffeine. Caffeine decreased MFR in both groups.