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Normal Vascular Aging: Differential Effects on Wave Reflection and Aortic Pulse Wave Velocity

The Anglo-Cardiff Collaborative Trial (ACCT)

Carmel M. McEniery, PhD^_*,_*, Yasmin, PhD^_*, Ian R. Hall, MB, MRCP, Ahmad Qasem, PhD, Ian B. Wilkinson, MA, DM, MRCP^_*, John R. Cockcroft, BSc, MB, FRCP on behalf of the ACCT Investigators

^_* Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, United Kingdom
Department of Cardiology, University of Wales, College of Medicine, University Hospital, Cardiff, United Kingdom
Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia

View larger version (18K): [in a new window]   Figure 1 Blood pressure averaged for deciles of age for males (left) and females (right). Symbols represent peripheral systolic (closed triangles), central systolic (open triangles), and diastolic (closed squares) blood pressures.

View larger version (14K): [in a new window]   Figure 2 Regression curves representing the effect of age on parameters of arterial stiffness and wave reflection for males (circles, solid lines) and females (squares, dashed lines). Panel A represents augmentation pressure (open circles/open squares) and augmentation index (closed circles/closed squares). Panel B represents aortic pulse wave velocity. Data points are the group means for each decile of age. The estimated functions for these relationships appear in Table 2.