Effects of Fluvastatin on the Carotid Arterial Media as Assessed by Integrated Backscatter Ultrasound Compared With Pulse-Wave Velocity
Haruko Yokoyama, MD,
Masanori Kawasaki, MD, PhD*,
Yoko Ito, MD, PhD,
Shinya Minatoguchi, MD, PhD and
Hisayoshi Fujiwara, MD, PhD
Regeneration & Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan
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Figure 1 Integrated backscatter (IB) image from the carotid artery. (A) Conventional ultrasound image of common carotid artery. Intima-media thickness and diameter of artery were measured on conventional ultrasound image. Bar = 1 cm. (B and C) Integrated backscatter values in the entire far wall of the arteries (an angle span of 30° between –15° and +15°) were measured. The IB values were determined averaging the IB values from 10 sites continuously moving the region of interest above the far arterial site. Also, IB values of arterial lumen were measured just above far wall shown by an asterisk. Bar = 1 cm.
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Figure 2 Correlation among integrated backscatter (IB) values, ultrasound parameters, and pulse-wave velocity (PWV) of the patients with hyperlipidemia at baseline. (A) Correlation between IB values and PWV. (B) Correlation between IB values and stiffness beta. (C) Correlation between IB values and intima-media thickness. (D) Correlation between IB values and age.
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Figure 3 Comparison of integrated backscatter (IB) values between the patients with atherosclerotic risk factors and without risk factors. Values represent mean ± one SD. CAD = history of coronary artery disease; CVD = history of cerebrovascular disease; DM = diabetes mellitus; HTN = hypertension.
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) of integrated backscatter (IB) values between at baseline and after 12 months and