Prognosis of "Masked" Hypertension and "White-Coat" Hypertension Detected by 24-h Ambulatory Blood Pressure Monitoring
10-Year Follow-Up From the Ohasama Study
Takayoshi Ohkubo, MD, PhD*, ,||,*,
Masahiro Kikuya, MD, PhD*,,
Hirohito Metoki, MD ,,||,
Kei Asayama, MD,,||,
Taku Obara, MS,,
Junichiro Hashimoto, MD, PhD*,,||,
Kazuhito Totsune, MD, PhD,,||,
Haruhisa Hoshi, MD, PhD¶,
Hiroshi Satoh, MD, PhD ,,|| and
Yutaka Imai, MD, PhD,,||
* Departments of Planning for Drug Development and Clinical Evaluation
Clinical Pharmacology and Therapeutics
Environmental Health Science
Tohoku University Graduate School of Pharmaceutical Science and Medicine
|| Tohoku University 21st Century COE Program "Comprehensive Research and Education Center for Planning of Drug Development and Clinical Evaluation," Sendai
¶ Ohasama Hospital, Iwate, Japan
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Figure 1 Relative hazards (RH) and 95% confidence intervals (CI) of sustained normal blood pressure (SNBP), white-coat hypertension (WCHT), masked hypertension (MHT), and sustained hypertension (SHT) for cardiovascular disease (CVD) mortality, stroke morbidity, and the composite of CVD mortality/stroke morbidity. Numbers inside bars indicate 95% CI. The SNBP group was treated as the reference category.
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Figure 2 Relative hazards (RH) and 95% confidence intervals (CI) of sustained normal blood pressure (SNBP), white-coat hypertension (WCHT), masked hypertension (MHT), and sustained hypertension (SHT) for risk of the composite of cardiovascular disease (CVD) mortality/stroke morbidity by gender. Numbers inside bars indicate 95% CI. The SNBP group was treated as the reference category.
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Figure 3 Relative hazards (RH) and 95% confidence intervals (CI) of sustained normal blood pressure (SNBP), white-coat hypertension (WCHT), masked hypertension (MHT), and sustained hypertension (SHT) for risk of the composite of cardiovascular disease (CVD) mortality/stroke morbidity by use of antihypertensive treatment. Treated subjects, subjects treated using antihypertensive medication; Untreated subjects, subjects not treated using antihypertensive medication. Numbers inside bars indicate 95% CI. The SNBP group was treated as the reference category.
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Figure 4 Relative hazards (RH) and 95% confidence intervals (CI) of sustained normal blood pressure (SNBP), white-coat hypertension (WCHT), masked hypertension (MHT), and sustained hypertension (SHT) for risk of the composite of cardiovascular disease (CVD) mortality/stroke morbidity by CVD risk profile. Low-risk group, patients without history of CVD or diabetes and with no risk factors; Middle-risk group, patients without history of CVD or diabetes but with one to two risk factors; High-risk group, patients with history of CVD or diabetes or with three risk factors. Numbers inside bars indicate 95% CI. The SNBP group was treated as the reference category.
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