Dynamic Cardiovascular Risk Assessment in Elderly PeopleThe Role of Repeated N-Terminal Pro–B-Type Natriuretic Peptide Testing
Christopher R. deFilippi, MD*,*,
Robert H. Christenson, PhD ,
John S. Gottdiener, MD*,
Willem J. Kop, PhD* and
Stephen L. Seliger, MD, MS
* Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland
Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland
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Figure 1 Flow Diagram of CHS Participants
The CHS (Cardiovascular Health Study) trial participants with blood samples available for N-terminal pro–B-type natriuretic peptide (NT-proBNP) testing at baseline and follow-up visits. *No study visit or only phone-based visit. HF = heart failure.
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Figure 2 Hazard Ratios for New-Onset HF by Decile of NT-proBNP
Demographic-adjusted hazard ratios for developing new-onset HF by decile of baseline NT-proBNP level. Abbreviations as in Figure 1.
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Figure 3 Kaplan-Meier Plots Based on Quintile of NT-proBNP
Unadjusted Kaplan-Meier plots for (A) time to new-onset HF diagnosis and (B) time to cardiovascular death based on the quintile (Q) of the baseline visit NT-proBNP level. Abbreviations as in Figure 1.
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Figure 4 Incident Rates for CV Outcomes Based on Change in NT-proBNP Level
Incident rates for (A) new-onset HF and (B) cardiovascular (CV) death based on change or absence of change between baseline and follow-up NT-proBNP levels. Change in NT-proBNP level is defined among those with a baseline NT-proBNP <190 pg/ml as either a decrease in NT-proBNP of at least 25% or an increase of at least 25% to a level  190 pg/ml. Change in NT-proBNP level is defined among those with a baseline NT-proBNP 190 pg/ml as either a decline of at least 25% to a level <190 pg/ml or an increase of >25%. Abbreviations as in Figure 1.
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