Beneficial Cardiovascular Effects of Bariatric Surgical and Dietary Weight Loss in Obesity
Oliver J. Rider, BM, BCh, MRCP*,
Jane M. Francis, DCR, DNM*,
Mohammed K. Ali, MSc*,
Steffen E. Petersen, MD, DPhil*,
Monique Robinson, MSc, MB, ChB, DPhil*,
Matthew D. Robson, PhD*,
James P. Byrne, MB, ChB, MD ,
Kieran Clarke, PhD and
Stefan Neubauer, MD, FMedSci*,*
* Department of Cardiovascular Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom
Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, United Kingdom
Department of Upper Gastrointestinal Surgery, Southampton, United Kingdom
View larger version (53K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 1 MR Images Before and After Weight Loss
Magnetic resonance (MR) transverse T1-weighted turbo spin echo images at the level of L5 before (Pre) and after (Post) diet-induced weight loss, demonstrating the substantial difference in both visceral and subcutaneous fat mass.
|
|
View larger version (14K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 2 Ventricular Structure
Ventricular structure of (A) dietary weight loss, (B) bariatric surgery, and (C) continued obesity. Open bars = pre-intervention; solid bars = post-intervention. *p < 0.05. LV = left ventricle; LVEDV = left ventricular end-diastolic volume; NS = not significant (p > 0.05); RV = right ventricle; RVEDV = right ventricular end-diastolic volume.
|
|
View larger version (21K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 3 Beneficial Effect of Weight Loss
Pooled analysis for both dietary and surgical weight loss: (A) left ventricular diastolic function (red solid line = obese after weight loss; blue dashed line = obese before weight loss; black solid line = normal weight); and (B) aortic distensibility (white bars = normal weight; blue bars = obese before weight loss; red bars = obese after weight loss). NS = not significant.
|
|
View larger version (11K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 4 Diastolic Dysfunction
Mean filling curves for (A) dietary weight loss, (B) bariatric surgery, and (C) continued obesity. Black solid lines indicate normal weight; blue solid lines indicate obese before weight loss; red dotted lines indicate obese after weight loss. *p < 0.05. NS indicates not significant (p > 0.05).
|
|
View larger version (21K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 5 Aortic Elastic Function
(A) Dietary weight loss, (B) bariatric surgery, and (C) continued obesity. Open bars = pre-intervention; solid bars = post-intervention. *p < 0.05. NS indicates not significant (p > 0.05). AO = ascending aorta; DDA = distal descending aorta; PDA = proximal descending aorta.
|
|
|
