Prevalence and Pathophysiologic Attributes of Ventricular Dyssynchrony in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Laurens F. Tops, MD*, ,
Kalpana Prakasa, MD*,
Harikrishna Tandri, MD*,
Darshan Dalal, MD*,
Rahul Jain, MD*,
Veronica L. Dimaano, MD*,
David Dombroski, MD ,
Cynthia James, PhD*,
Crystal Tichnell, MGC*,
Amy Daly, MSc*,
Frank Marcus, MD ,
Martin J. Schalij, MD,
Jeroen J. Bax, MD,
David Bluemke, MD,
Hugh Calkins, MD* and
Theodore P. Abraham, MD*,*
* Division of Cardiology, Department of Medicine, Johns Hopkins Hospital, Baltimore, Maryland
Department of Radiology, Johns Hopkins Hospital, Baltimore, Maryland
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands
Sarver Heart Center, University of Arizona College of Medicine, Tucson, Arizona
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Figure 1 Example of an ARVD/C Patient With Significant RV Dyssynchrony
Samples are placed at the basal parts of the septum (yellow curve), right ventricular (RV) free wall (red curve), and left ventricular (LV) lateral wall (green curve). In this patient, a significant delay between the septum and the RV free wall was present (110 ms), indicated by the yellow and red arrows. ARVD/C = arrhythmogenic right ventricular dysplasia/cardiomyopathy; AVC = aortic valve closure; AVO = aortic valve opening.
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Figure 2 RVFAC and RV Peak Systolic Strain in Control Subjects and ARVD/C Patients
Right ventricular fractional area change (RVFAC) (upper panel) and RV peak systolic strain (lower panel) in the 25 control subjects, 26 ARVD/C patients without RV dyssynchrony (DYSS), and 26 ARVD/C patients with RV DYSS. Both RVFAC and RV peak systolic strain were significantly decreased in the ARVD/C patients with RV DYSS. Abbreviations as in Figure 1.
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