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Effect of Moderate Diet-Induced Weight Loss and Weight Regain on Cardiovascular Structure and Function

Lisa de las Fuentes, MD^_*, Alan D. Waggoner, MHS^_*, B. Selma Mohammed, MD, PhD, Richard I. Stein, PhD, Bernard V. Miller, III, MD, Gary D. Foster, PhD, Holly R. Wyatt, MD, Samuel Klein, MD and Victor G. Davila-Roman, MD^_*,_*

^_* Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri
Center for Human Nutrition, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri
Center for Obesity Research and Education, Departments of Medicine and Public Health, Temple University School of Medicine, Philadelphia, Pennsylvania
Center for Human Nutrition, Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado

View larger version (36K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Cardiovascular Structure-Function Response to Weight Loss Mean (± SEM) change in (A) early diastolic myocardial velocity (E'), (B) systolic myocardial velocity (S'), (C) left ventricular mass indexed to height2.7 (LVM/Ht2.7), and (D) carotid intima-media thickness in the combined cohort (blue bars) with weight change (red line) shown for reference. The combined group had 60 subjects at baseline and 3 months, 56 subjects at 6 months, and 47 subjects at 12 and 24 months. There was no significant difference between diet groups for any of these phenotypes. *Adjusted p 0.005; adjusted p 0.05 versus baseline.