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Clinical Benefits of Remote Versus Transtelephonic Monitoring of Implanted Pacemakers

George H. Crossley, MD^_*,_*, Jane Chen, MD, Wassim Choucair, MD, Todd J. Cohen, MD, Douglas C. Gohn, MD^||, W. Ben Johnson, MD^¶, Eleanor E. Kennedy, MD^#, Luc R. Mongeon, PhD^_**, Gerald A. Serwer, MD, Hongyan Qiao^_**, Bruce L. Wilkoff, MD for the PREFER Study Investigators

^_* St. Thomas Research Institute and University of Tennessee College of Medicine, Nashville, Tennessee
Department of Internal Medicine, Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri
Cardiology Associates of Corpus Christi, Corpus Christi, Texas
Department of Medicine, Winthrop University Hospital, Mineola, New York
^|| The Heart Group, Lancaster, Pennsylvania
^¶ Iowa Heart Center, Des Moines, Iowa
^# Heart Clinic Arkansas, Little Rock, Arkansas
^_** Medtronic, Inc., Minneapolis, Minnesota
Department of Pediatrics, University of Michigan Congenital Heart Center, University of Michigan Health System, Ann Arbor, Michigan
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio

View larger version (26K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Study Design Depiction of required follow-up, remote and in-office, for patients in the Remote and Control arms. TTM = transtelephonic monitoring.

View larger version (23K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Patient Flowchart The distribution, relative to inclusion in the analysis cohort and randomization assignment, of all enrolled patients. Mean follow-up: 375 ± 140 days.

View larger version (14K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Composite CAE Survival curves represent the difference in probability of clinically actionable event (CAE) identification between the Remote and Control arms. TTM = transtelephonic monitoring.

View larger version (11K): [in this window] [in a new window] [Download PPT slide]   Figure 4 CAE Rate by Source The number of clinically actionable events (CAEs) by their source. The number of CAEs discovered by transtelephonic monitoring (TTM) per year in the TTM arm was very small (0.01).