The Relative Efficacy and Safety of Clopidogrel in Women and MenA Sex-Specific Collaborative Meta-Analysis
Jeffrey S. Berger, MD*,*,
Deepak L. Bhatt, MD, MPH , ,
Christopher P. Cannon, MD,
Zhengming Chen, MBBS, DPhil ,
Lixin Jiang, MBBS, MSc||,
James B. Jones, PhD, MBA,
Shamir R. Mehta, MD¶,
Marc S. Sabatine, MD, MPH,#,
Steven R. Steinhubl, MD,
Eric J. Topol, MD** and
Peter B. Berger, MD
* New York University School of Medicine, New York, New York
VA Boston Healthcare System, Boston, Massachusetts
Brigham and Women's Hospital, Boston, Massachusetts
University of Oxford, Oxford, England
|| Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing, China
¶ McMaster University, Hamilton, Ontario, Canada
# Harvard Medical School, Boston, Massachusetts
** Scripps Translational Research Institute, La Jolla, California
Geisinger Clinic, Danville, Pennsylvania
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Figure 2 Effect of Clopidogrel Treatment on the Effect of Major Cardiovascular Events
Major cardiovascular events are defined as the composite of nonfatal myocardial infarction, nonfatal stroke, and cardiovascular death. Pooled ORs are from a random-effects model. Sizes of data markers are proportional to the amount of data contributed by each trial. CHARISMA = Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management, and Avoidance; CI = confidence interval; CLARITY–TIMI 28 = Clopidogrel as Adjunctive Reperfusion Therapy–Thrombolysis In Myocardial Infarction 28; COMMIT = Clopidogrel and Metoprolol in Myocardial Infarction Trial; CREDO = Clopidogrel for the Reduction of Events During Observation; CURE = Clopidogrel in Unstable Angina to Prevent Recurrent Events; OR = odds ratio.
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Figure 3 Effect of Clopidogrel Treatment on the Effect of All-Cause Mortality
Pooled ORs are from a random-effects model. Sizes of data markers are proportional to the amount of data contributed by each trial. Abbreviations as in Figure 2.
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Figure 4 Effect of Clopidogrel Treatment on the Effect of Myocardial Infarction
Pooled ORs are from a random-effects model. Sizes of data markers are proportional to the amount of data contributed by each trial. Abbreviations as in Figure 2.
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Figure 5 Effect of Clopidogrel Treatment on the Effect of Stroke
Pooled ORs are from a random-effects model. Sizes of data markers are proportional to the amount of data contributed by each trial. Abbreviations as in Figure 2.
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Figure 6 Effect of Clopidogrel Treatment on the Effect of Major Bleeding
Pooled ORs are from a random-effects model. Sizes of data markers are proportional to the amount of data contributed by each trial. Abbreviations as in Figure 2.
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