Effects of High-Dose Modified-Release Nicotinic Acid on Atherosclerosis and Vascular FunctionA Randomized, Placebo-Controlled, Magnetic Resonance Imaging Study
Justin M.S. Lee, MB, BCh*,
Matthew D. Robson, PhD*,
Ly-Mee Yu, MSc ,
Cheerag C. Shirodaria, MD*,
Colin Cunnington, MBBS*,
Ilias Kylintireas, MD*,
Janet E. Digby, PhD*,
Thomas Bannister, BA*,
Ashok Handa, MB, BS ,
Frank Wiesmann, MD*,
Paul N. Durrington, MD ,
Keith M. Channon, MD*,
Stefan Neubauer, MD* and
Robin P. Choudhury, DM*,*
* Department of Cardiovascular Medicine, University of Oxford and Oxford Centre for Clinical Magnetic Resonance Research (OCMR), Oxford, United Kingdom
Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom
Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom
Cardiovascular Research Group, University of Manchester, Manchester, United Kingdom
View larger version (11K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 2 Effects of NA Treatment on Change in Mean Wall Area of the Carotid Arteries Quantified by MRI
Bars indicate mean (SD) combined change for the right and left carotid arteries at 6 months (open bars) and 12 months (solid bars). Within group, the mean change in carotid wall area at 12 months was –1.1 ± 2.6 mm2 for nicotinic acid (NA) and +1.2 ± 3.0 mm2 for placebo. For the primary end point, the NA group had significantly greater change in carotid wall area at 12 months compared with placebo (adjusted treatment difference: –1.64 mm2 [95% confidence interval: –3.12 to –0.16]; p = 0.03). MRI = magnetic resonance imaging.
|
|
View larger version (97K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 3 Atheroma Regression and Progression
Magnetic resonance images of carotid arteries in cross section, obtained at baseline and at 12 months, showing atheroma progression and regression in placebo and nicotinic acid-treated patients.
|
|
View larger version (13K):
[in this window]
[in a new window]
[Download PPT slide]
|
Figure 4 Change in Carotid Wall Area Versus HDL-C and LDL-C
(A) Scatterplot of 12-month change in carotid wall area (CWA) versus 12-month change in high-density lipoprotein cholesterol (HDL-C). (B) Scatterplot of 12-month change in CWA versus 12-month change in low-density lipoprotein cholesterol (LDL-C). Open circles indicate placebo group and solid circles nicotinic acid-treated group.
|
|
|
