Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone
George J. Mak, MD*, ,
Mark T. Ledwidge, PhD*,
Chris J. Watson, PhD,
Dermot M. Phelan, MD*,,
Ian R. Dawkins, DPhil*,
Niamh F. Murphy, MD, PhD*,
Anil K. Patle, BTech*,
John A. Baugh, PhD and
Kenneth M. McDonald, MD*,*
* Heart Failure Unit, St. Vincent's University Hospital, Dublin, Ireland
Conway Institute of Biomolecular and Biomedical Research, University College, Dublin, Ireland
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Figure 2 Change in Mean PIIINP Levels Between Eplerenone and Control Group From Baseline to 12 Months
Over 12 months, eplerenone attenuated a rise in mean pro-collagen type-III aminoterminal peptide (PIIINP) levels in comparison with the control group. Box plots presented have a box with ends at quartiles Q1 and Q3, with the statistical median represented by the horizontal line in the box; whiskers extend to 1.5 times the box width (interquartile range) from either end of the box.
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Figure 3 Change in Deceleration Time Between Eplerenone and Control Group From Baseline to 12 Months
Over 12 months, the deceleration time in the eplerenone group was significantly reduced in comparison with the control group. Box plots presented have a box with ends at quartiles Q1 and Q3, with the statistical median represented by the horizontal line in the box; whiskers extend to 1.5 times the box width (interquartile range) from either end of the box.
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