Hunting for the "Sweet Spot" in P2Y12 Receptor Blockade*
Daniel I. Simon, MD and
Sahil A. Parikh, MD*
University Hospitals Harrington-McLaughlin Heart & Vascular Institute, Case Western Reserve University School of Medicine, Cleveland, Ohio
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Figure 1 Potential Role of P2Y12 Antagonism in Reversing Platelet Aggregation and Thrombosis
P2Y12 signaling after platelet stimulation by thrombin or collagen promotes activation of the receptor function of glycoprotein (GP) IIb/IIIa, fibrinogen binding, and platelet aggregation. Since continued P2Y12 signaling is required to maintain the activation state of GP IIb/IIIa and aggregate stability, addition of P2Y12 antagonists to aggregated platelets in a thrombus is capable of reversing thrombosis. ADP = adenosine diphosphate; vWf = von Willebrand factor.
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