Role of Clopidogrel Loading Dose in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary AngioplastyResults From the HORIZONS-AMI (Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction) Trial
George Dangas, MD, PhD*, ,*,
Roxana Mehran, MD*,,
Giulio Guagliumi, MD ,
Adriano Caixeta, MD, PhD*,,
Bernhard Witzenbichler, MD ,
Jiro Aoki, MD, PhD*,,
Jan Z. Peruga, MD||,
Bruce R. Brodie, MD¶,
Dariusz Dudek, MD#,
Ran Kornowski, MD**,
LeRoy E. Rabbani, MD*,
Helen Parise, ScD*,,
Gregg W. Stone, MD*, for the HORIZONS-AMI Trial Investigators
* Columbia University Medical Center, New York, New York
Cardiovascular Research Foundation, New York, New York
Ospedali Riuniti di Bergamo, Bergamo, Italy
Charité Universitätsmedizin Campus Benjamin Franklin, Berlin, Germany
|| Department of Cardiology Medical University in Lodz Bieganski Hospital, Lodz, Poland
¶ LeBauer Cardiovascular Research Foundation and Moses Cone Hospital, Greensboro, North Carolina
# Jagiellonian University, Krakow, Poland
** Rabin Medical Center, Petach Tikva, Israel
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Figure 1 Flow Chart of the Present Study
Enrollment and follow-up of the patients (pts) in the trial. HORIZONS-AMI = Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction; STEMI = ST-segment elevation myocardial infarction.
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Figure 3 Clinical Outcomes at 30 Days According to Stratification
Clinical outcomes according to clopidogrel loading dose stratified treatment within the bivalirudin monotherapy and the unfractionated heparin plus glycoprotein IIb/IIIa inhibitor arms. MACE = major adverse cardiac events; NACE = net adverse clinical events.
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Figure 4 Clinical Outcomes at 30 Days According to Randomized Assignments
Clinical outcomes according to randomization to bivalirudin (Biv) monotherapy versus unfractionated heparin (UFH) plus glycoprotein IIb/IIIa inhibitor (GPI) within the groups of 600- and 300-mg clopidogrel loading doses. Abbreviations as in Figure 3.
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