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Association of Chronic Kidney Disease With the Spectrum of Ankle Brachial Index

The CHS (Cardiovascular Health Study)

Joachim H. Ix, MD, MAS^_*,,,_*, Ronit Katz, DPhil^||, Ian H. De Boer, MD, MS^¶,#, Brian R. Kestenbaum, MD, MS^¶, Matthew A. Allison, MD, MPH, David S. Siscovick, MD, MPH^||, Anne B. Newman, MD, MPH^_**, Mark J. Sarnak, MD, MS, Michael G. Shlipak, MD, MPH^, and Michael H. Criqui, MD, MPH^,

^_* Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California
Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California San Diego, San Diego, California
Division of Cardiology, Department of Medicine, University of California San Diego, San Diego, California
Nephrology Section, Veterans Affairs San Diego Healthcare System, San Diego, California
^|| Collaborative Health Studies Coordinating Center, Department of Biostatistics, University of Washington, Seattle, Washington
^¶ Division of Nephrology, Department of Medicine, University of Washington, Seattle, Washington
^# Nephrology Section, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington
^_** Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania
Division of Nephrology, Department of Medicine, Tufts-New England Medical Center, Boston, Massachusetts
Department of Medicine, University of California San Francisco, San Francisco, California
General Medicine Section, San Francisco Veterans Affairs Medical Center, San Francisco, California

View larger version (11K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Estimated GFR by Ankle-Brachial Index A natural cubic spline function. The solid line represents mean adjusted glomerular filtration rate (GFR), and dotted lines represent 95% confidence intervals. The spline function was adjusted for age, sex, race, hypertension, diabetes, smoking, body mass index, low-density lipoprotein, high-density lipoprotein, and C-reactive protein.

View larger version (7K): [in this window] [in a new window] [Download PPT slide]   Figure 2 The Association of the Spectrum of GFR With Low and High Ankle Brachial Index Natural cubic spline function. The solid line represents relative risk, and dotted lines represent 95% confidence intervals. Both spline functions were adjusted for age, sex, race/ethnicity, hypertension, diabetes, smoking, body mass index, low-density lipoprotein, high-density lipoprotein, and C-reactive protein. Abbreviation as in Figure 1.