Regadenoson: A New Myocardial Stress Agent
Wael Al Jaroudi, MD* and
Ami E. Iskandrian, MD
Division of Cardiovascular Diseases, Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama
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Figure 2 Comparison of Regadenoson Versus Adenosine on Vascular Resistance in Dogs
Regadenoson caused a smaller decrease in systemic vascular resistance compared with adenosine. Both drugs reduced mesenteric vascular resistance to the same extent. *p < 0.05. The error bars represent the standard error of the means.
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Figure 3 Effect of Aminophylline Infusion on Regadenoson-Mediated Coronary Vasodilation in Human Volunteers
Aminophylline injection (100 mg) did not affect the peak-to-baseline coronary flow velocity reserve (CFVR) ratio, but significantly blunted the duration of hyperemia (2-fold increase in CFVR above baseline). *p < 0.05.
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Figure 4 Regadenoson/Rest SPECT Images Showing a Large Reversible Perfusion Abnormality in the Inferior and Lateral Segments of the LV Myocardium
By quantitative analysis, the abnormality involved 29% of the myocardium. The patient is a 54-year-old man with chest pains. LV = left ventricular; SPECT = single-photon emission computed tomography.
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Figure 5 Changes in HR and Blood Pressure With Regadenoson Versus Adenosine
Regadenoson bolus administration caused a greater increase in maximal heart rate (HR) than did an adenosine infusion (*p < 0.05). Effects of regadenoson and adenosine on systolic and diastolic blood pressure (BP) were not statistically different. The error bars represent standard error of the mean.
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Figure 6 Summed Symptom Score With Regadenoson and Adenosine
The mean summed symptom score for chest pain, dyspnea, and flushing, and the mean summed score of all the symptoms were significantly lower in the regadenoson versus adenosine groups (*p < 0.05). The score for each symptom was calculated as: 0, absent; 1, mild; 2, moderate; and 3, severe. The error bars represent standard error of the mean.
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