Influence of Continuous Infusion of Low-Dose Human Atrial Natriuretic Peptide on Renal Function During Cardiac SurgeryA Randomized Controlled Study
Akira Sezai, MD, PhD*,*,
Mitsumasa Hata, MD, PhD*,
Tetsuya Niino, MD, PhD*,
Isamu Yoshitake, MD, PhD*,
Satoshi Unosawa, MD, PhD*,
Shinji Wakui, MD, PhD*,
Shunji Osaka, MD, PhD*,
Tadateru Takayama, MD, PhD ,
Yuji Kasamaki, MD, PhD,
Atsushi Hirayama, MD, PhD and
Kazutomo Minami, MD, PhD*
* Department of Cardiovascular Surgery, Nihon University School of Medicine, Tokyo, Japan
Department of Cardiology, Nihon University School of Medicine, Tokyo, Japan
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Figure 1 Changes of Creatinine Clearance
Creatinine clearance was significantly higher in the human atrial natriuretic peptide (hANP) group from post-operative day 0 to week 1. *p < 0.05.
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Figure 2 Changes of ANP and Plasma Renin Activity
Atrial natriuretic peptide (ANP) increased rapidly in the human atrial natriuretic peptide (hANP) group and was significantly higher than in the placebo group until post-operative day 3, but there was no significant difference between the 2 groups at post-operative week 1. Renin was significantly lower in the hANP group excluding day 1. *p < 0.05.
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Figure 3 Changes of Angiotensin-II and Aldosterone
The levels of angiotensin-II and aldosterone increased post-operatively in the placebo group, and reached a peak at the time of the return to intensive care unit. Angiotensin-II and aldosterone were significantly lower in the human atrial natriuretic peptide (hANP) group throughout the study. *p < 0.05.
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