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Effect of Long-Acting Testosterone Treatment on Functional Exercise Capacity, Skeletal Muscle Performance, Insulin Resistance, and Baroreflex Sensitivity in Elderly Patients With Chronic Heart Failure

A Double-Blind, Placebo-Controlled, Randomized Study

Giuseppe Caminiti, MD^_*, Maurizio Volterrani, MD^_*, Ferdinando Iellamo, MD^_*,,_*, Giuseppe Marazzi, MD^_*, Rosalba Massaro, MD^_*, Marco Miceli, MD^_*, Caterina Mammi, MD^_*, Massimo Piepoli, MD, Massimo Fini, MD^_* and Giuseppe M.C. Rosano, MD^_*

^_* Centre for Clinical and Basic Research, Cardiovascular Research Unit, Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy
Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
Department of Cardiology, "Guglielmo da Saliceto" Hospital, Piacenza, Italy

View larger version (6K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Relation Between Changes () in Total Testosterone Levels and in Peak VO2 in the Testosterone-Treated Group In heart failure patients treated with testosterone, there was a significant direct relationship between the increase in plasma levels of testosterone and the increase in peak oxygen consumption (VO2).

View larger version (6K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Relation Between Changes () in Total Testosterone Levels and in MVC in the Testosterone-Treated Group In heart failure patients treated with testosterone, there was a significant direct relationship between the increase in plasma levels of testosterone and the increase in maximal isometric muscle strength (maximal voluntary contraction [MVC]).