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9-Month Clinical, Angiographic, and Intravascular Ultrasound Results of a Prospective Evaluation of the Axxess Self-Expanding Biolimus A9-Eluting Stent in Coronary Bifurcation Lesions

The DIVERGE (Drug-Eluting Stent Intervention for Treating Side Branches Effectively) Study

Stefan Verheye, MD, PhD^_*,_*, Pierfrancesco Agostoni, MD^_*, Christophe L. Dubois, MD, Joseph Dens, MD, PhD, John Ormiston, MD, Stephen Worthley, MD^||, Brett Trauthen, MS^¶, Takao Hasegawa, MD^#, Bon-Kwon Koo, MD, PhD^#, Peter J. Fitzgerald, MD, PhD^#, Roxana Mehran, MD^_** and Alexandra J. Lansky, MD^_**

^_* Antwerp Cardiovascular Institute Middelheim, Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium
University Hospital Gasthuisberg, Leuven, Belgium
Oost-Limburg Hospital, Genk, Belgium
Auckland City Hospital, Auckland, New Zealand
^|| Royal Adelaide Hospital, Adelaide, Australia
^¶ Devax, Inc., Lake Forest, California
^# Stanford University Medical Center, Stanford, California
^_** Columbia University Medical Center and Cardiovascular Research Foundation, New York, New York

View larger version (120K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Fluoroscopic Image Showing Partially Deployed Stent Position Within Bifurcation Lesion Stent (thin arrows) and cover sheath (thick arrow) markers are clearly visible.

View larger version (33K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Final Placement Angiogram (A) Contrast-filled angiogram shows the Axxess stent in the proximal left anterior descending artery (LAD) (left anterior oblique artery view with 1 marker at the level of the mid-LAD and 2 markers in the diagonal branch) and an additional Cypher in the mid-LAD. (B) Stent boost image shows an enhanced contrast-negative stent visualization.

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Flow Diagram of Subjects' Progress Through Phases of the DIVERGE Study DIVERGE = Drug-Eluting Stent Intervention for Treating Side Branches Effectively; FU = follow-up; IVUS = intravascular ultrasound.

View larger version (15K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Deployment Patterns Observed in the DIVERGE Study DIVERGE = Drug-Eluting Stent Intervention for Treating Side Branches Effectively; PV = parent vessel; SB = side branch.