Role of Reticulated Platelets and Platelet Size Heterogeneity on Platelet Activity After Dual Antiplatelet Therapy With Aspirin and Clopidogrel in Patients With Stable Coronary Artery Disease
Sasidhar Guthikonda, MD, MPH, FACC*,
Carlos L. Alviar, MD*,
Muthiah Vaduganathan, BS*,
Mehmet Arikan, MD*,
Armando Tellez, MD*,
Timothy DeLao, MLT*,
Juan F. Granada, MD*,
Jing-Fei Dong, MD, PhD ,
Neal S. Kleiman, MD, FACC*,* and
Eli I. Lev, MD*
* Department of Cardiology, Methodist DeBakey Heart and Vascular Center and Methodist Hospital Research Institute, Houston, Texas
Department of Thrombosis, Baylor College of Medicine, Houston, Texas.
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Figure 1 Aggregation of Reticulated Platelets in Response to 5-µM ADP, 1.5-mmol/l AA, and 1-µg/ml Collagen
Mean ± SEM; p value for t test upper versus lower tertile. AA = arachidonic acid; ADP = adenosine diphosphate.
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Figure 2 Percentage of Patients With Low Responses in Tertiles of Reticulated Platelets
Percentage of patients with low responses to aspirin (ASA-LR), clopidogrel (CLO-LR), and both aspirin and clopidogrel (ASA+CLO-LR) in tertiles of reticulated platelets. p values were determined using chi-square test among the 3 tertiles.
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Figure 4 P-Selectin and GP IIb/IIIa Expression in Small, Large, and All Platelets
P-selectin and glycoprotein (GP) IIb/IIIa expression in small (lower 20%), large (upper 20%), and all platelets, expressed as mean fluorescence intensity (MFI). Mean ± SEM; p value for t test large versus small platelets.
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