Association of Genetic Variation on Chromosome 9p21 With Susceptibility and Progression of AtherosclerosisA Population-Based, Prospective Study
Shu Ye, MD, PhD, MRCPath*,*,
Johann Willeit, MD ,
Florian Kronenberg, MD ,
Qingbo Xu, MD, PhD and
Stefan Kiechl, MD
* Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine, London, United Kingdom
Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria
Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria
Cardiovascular Division, The James Black Centre, Kings College London, London, United Kingdom.
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Figure 1 Cumulative Hazard Curves of Incident CVD by Genotype
Cumulative hazard curves (with multivariable adjustment) of incident cardiovascular disease (CVD) from 1995 to 2005 for groups of subjects of the GG, GC, and CC genotypes of the rs1333049 polymorphism. rs= reference single nucleotide polymorphism.
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Figure 2 Hazard Ratios of Incident CVD According to WHR and Genotype
Hazard ratios of incident cardiovascular disease calculated for a 0.1-U increase in the waist-to-hip ratio (WHR) in subgroups according to rs1333049 genotypes (GG, GC, CC). The figure shows that the strength of association between waist-to-hip ratio and cardiovascular disease risk increases with the number of copies of the C allele (p = 0.006 for effect modification in a model adjusted for age and gender). Abbreviations as in Figure 1.
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