Coronary Computed Tomography Angiography as a Screening Tool for the Detection of Occult Coronary Artery Disease in Asymptomatic Individuals
Eue-Keun Choi, MD*,
Sang Il Choi, MD ,
Juan J. Rivera, MD ,
Khurram Nasir, MD ,
Sung-A. Chang, MD*,
Eun Ju Chun, MD,
Hyung-Kwan Kim, MD*,
Dong-Joo Choi, MD*,
Roger S. Blumenthal, MD and
Hyuk-Jae Chang, MD, PhD*,*
* Division of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea
Division of Radiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea
Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, Maryland
Massachusetts General Hospital Cardiac MRI, PET, CT Program, Boston, Massachusetts.
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Figure 1 Study Population on the Basis of the Results of Coronary Artery Calcium Scoring and CT Angiography
CAD = coronary artery disease; CT = computed tomography; MDCT = multidetector row computed tomography; pts = patients.
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Figure 2 Coronary Artery Disease According to Age Quartiles
The incidence of atherosclerotic plaques, significant stenosis, and moderate-to-severe coronary calcification increased with age. CACS = coronary artery calcium scores.
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Figure 3 Frequency of Significant Stenosis According to Age Groups
Relationship with (A) National Cholesterol Education Program (NCEP) Risk Groups and (B) coronary artery calcium score (CACS). Young adults with significant stenosis were classified into low risk and low CACS more often than older adults.
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Figure 4 Multidetector Row Computed Tomography and Coronary Angiography in a 49-Year-Old Male Subject
Curved multiplanar imaging (A) shows significant lesion located in the left anterior descending artery demonstrated by multidetector row computed tomography (arrows). Cross-sectional view (B) of dashed line in A demonstrates severe positive arterial remodeling of a mixed plaque. Volume-rendering imaging (C) shows severe discrete stenosis (degree of stenosis: 80%) located in the proximal left anterior descending artery (arrow). Conventional angiography (D) reveals significant stenosis at corresponding area of left anterior descending artery (arrow).
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