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Childhood Levels of Serum Apolipoproteins B and A-I Predict Carotid Intima-Media Thickness and Brachial Endothelial Function in Adulthood

The Cardiovascular Risk in Young Finns Study

Markus Juonala, MD, PhD^_*,_*, Jorma S.A. Viikari, MD, PhD^_*, Mika Kähönen, MD, PhD^¶,#, Tiina Solakivi, PhD^||, Hans Helenius, MSc, Antti Jula, MD, PhD^_**, Jukka Marniemi, PhD^_**, Leena Taittonen, MD, PhD^,, Tomi Laitinen, MD, PhD, Tapio Nikkari, MD, PhD^|| and Olli T. Raitakari, MD, PhD^,

^_* Department of Medicine, University of Turku, Turku, Finland
Department of Biostatistics, University of Turku, Turku, Finland
Department of Clinical Physiology, University of Turku, Turku, Finland
Cardiovascular Research Center, University of Turku, Turku, Finland
^|| Department of Medical Biochemistry, University of Tampere, Tampere, Finland
^¶ Department of Clinical Physiology, University of Tampere, Tampere, Finland
^# Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
^_** Department of Health and Functional Capacity, National Public Health Institute, Turku, Finland
Department of Pediatrics, University of Oulu, Oulu, Finland
Vaasa Central Hospital, Vaasa, Finland
Department of Clinical Physiology, University of Kuopio, Kuopio, Finland.

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 1 ROC Curves for Adolescent Lipid Measures Predicting Adulthood IMT 90th Percentile or Carotid Plaque Ages 12 to 18 years, n = 472. The diagonal line indicates a test with an area under the receiver operating characteristics curve of 0.5. In addition to lipid measures, the models included those risk factors significantly associated with intima-media thickness in multivariate model (blood pressure, smoking). The values for continuous variables were age- and gender-specific Z scores. ApoA-I = apolipoprotein A-I; ApoB = apolipoprotein B; HDL = high-density lipoprotein (cholesterol); IMT = intima-media thickness; LDL = low-density lipoprotein (cholesterol); ROC = receiver-operating characteristic.