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J Am Coll Cardiol, 2008; 52:266-272, doi:10.1016/j.jacc.2008.03.050
© 2008 by the American College of Cardiology Foundation
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Comparison of Copeptin, B-Type Natriuretic Peptide, and Amino-Terminal Pro-B-Type Natriuretic Peptide in Patients With Chronic Heart Failure

Prediction of Death at Different Stages of the Disease

Stephanie Neuhold, MD*, Martin Huelsmann, MD*,*, Guido Strunk, PhD{ddagger}, Brigitte Stoiser, MD{dagger}, Joachim Struck, PhD§, Nils G. Morgenthaler, MD§, Andreas Bergmann, PhD§, Deddo Moertl, MD*, Rudolf Berger, MD* and Richard Pacher, MD*

* Department of Cardiology, Medical University of Vienna, Vienna, Austria
{dagger} Department of Infectious Diseases, Medical University of Vienna, Vienna, Austria
{ddagger} Research Institute for Health Care Management and Economics, University of Economics and Business Administration, Vienna, Austria
§ B.R.A.H.M.S. AG, Hennigsdorf, Germany.


Figure 1
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Figure 1 Box Plots of Plasma BNP, Copeptin, and GFR

Median levels of BNP, copeptin, and GFR depending on NYHA functional class. BNP = brain natriuretic peptide; GFR = glomerular filtration rate; NYHA = New York Heart Association.

BNP = brain natriuretic peptide; GFR = glomerular filtration rate; NYHA = New York Heart Association.

 

Figure 2
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Figure 2 Quartiles of Copeptin

Kaplan-Meier plots: survival in patients grouped according to quartiles of plasma copeptin.

 

Figure 3
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Figure 3 ROC for 24-Month Survival

Area under receiver-operator characteristic (ROC) curves for 24-month survival for copeptin, BNP, and copeptin plus BNP. AUC = area under the receiver-operator characteristic curve; other abbreviations as in Figure 1.

 




 
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