Effect of Diabetes on Progression of Coronary Atherosclerosis and Arterial RemodelingA Pooled Analysis of 5 Intravascular Ultrasound Trials
Stephen J. Nicholls, MBBS, PhD*, ,*,
E. Murat Tuzcu, MD*,
Srinivasa Kalidindi, MD, MPH*,
Kathy Wolski, MPH*,
Keon-W. Moon, MD*,
Ilke Sipahi, MD*,
Paul Schoenhagen, MD* and
Steven E. Nissen, MD*
* Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio
Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio.
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Figure 1 LDL Lowering and Plaque Progression
Changes in percent atheroma volume (PAV) (top left) and total atheroma volume (TAV) (top right) and proportion of subjects undergoing substantial regression (at least 5% relative decrease in PAV, bottom left) and progression (at least 5% relative increase in percent atheroma volume, bottom right) in patients with and without diabetes mellitus (DM) stratified according to a level of low-density lipoprotein cholesterol (LDL-C) < or >80 mg/dl with treatment. LDL = low-density lipoprotein.
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Figure 2 CRP Lowering and Plaque Progression
Changes in PAV (top left) and TAV (top right) and proportion of subjects undergoing substantial regression (at least 5% relative decrease in percent atheroma volume, bottom left) and progression (at least 5% relative increase in percent atheroma volume, bottom right) in patients with and without DM stratified according to a level of C-reactive protein (CRP) < or >2 mg/l with treatment. Abbreviations as in Figure 1.
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