Extracellular Matrix Alterations in Patients With Paroxysmal and Persistent Atrial FibrillationBiochemical Assessment of Collagen Type-I Turnover
Eleftherios M. Kallergis, MD*,
Emmanuel G. Manios, MD*,
Emmanuel M. Kanoupakis, MD*,
Hercules E. Mavrakis, MD*,
Dimitris A. Arfanakis, MD*,
Niki E. Maliaraki, MD ,
Chrisovalantis E. Lathourakis, MD*,
Gregory I. Chlouverakis, PhD* and
Panos E. Vardas, MD, PhD, FESC, FACC*,*
* Department of Cardiology, University Hospital of Heraklion, Crete, Greece
Laboratory of Biochemistry, University Hospital of Heraklion, Crete, Greece.
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Figure 1 Comparative Levels of Serum Concentration of CICP
C-terminal propeptide of collagen type-I (CICP) showed a gradual increase from control subjects to paroxysmal and then to persistent atrial fibrillation (AF) patients as shown in this box plot.
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Figure 2 Box Plot of Serum Concentrations of CITP
C-terminal telopeptide of collagen type-I (CITP) in control subjects differed significantly compared with that in both paroxysmal and persistent atrial fibrillation (AF) patients.
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Figure 3 Intergroup Serum Concentrations of MMP-1
This box plot depicts matrix metalloproteinase (MMP)-1 levels that differed significantly between persistent and paroxysmal atrial fibrillation (AF) patients.
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Figure 4 Box Plot Depiction of the Differences in Levels of Serum TIMP-1
Tissue inhibitor of matrix metalloproteinase (TIMP)-1 levels differed significantly in all intergroup comparisons. AF = atrial fibrillation.
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Figure 5 Direct Correlation Between Serum Concentrations of CICP and LA Diameter Dimensions
In all AF patients taken together, there was a positive correlation between CICP and left atrial diameter (LA) dimension (r = 0.635, p < 0.001). Abbreviations as in Figure 1.
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