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Antiarrhythmic Effect of Reverse Ventricular Remodeling Induced by Cardiac Resynchronization Therapy

The InSync ICD (Implantable Cardioverter-Defibrillator) Italian Registry

Luigi Di Biase, MD^_*,, Maurizio Gasparini, MD, Maurizio Lunati, MD, Massimo Santini, MD^||, Maurizio Landolina, MD^¶, Giuseppe Boriani, MD^#, Antonio Curnis, MD^_**, Mario Bocchiardo, MD, Antonio Vincenti, MD, Alessandra Denaro, MS, Sergio Valsecchi, PhD, Andrea Natale, MD^{||||,##,¶¶,_*}, Luigi Padeletti, MD^_*** on behalf of the InSync/InSync ICD Italian Registry Investigators

^_* University of Foggia, Foggia, Italy
Cleveland Clinic, Cleveland, Ohio
IRCCS Istituto Clinico Humanitas, Rozzano (Milan), Italy
Niguarda Hospital, Milan, Italy
^|| S. Filippo Neri Hospital, Rome, Italy
^¶ Fondazione Policlinico S. Matteo IRCCS, Pavia, Italy
^# University of Bologna and Azienda Ospedaliera S. Orsola-Malpighi, Bologna, Italy
^_** Ospedali Civili, Brescia, Italy
Ospedale Civile, Asti, Italy
S. Gerardo dei Tintori, Monza, Italy
Medtronic Italia, Rome, Italy
^|||| Texas Cardiac Arrhythmia Institute at St. David's Medical Center, Austin, Texas
^¶¶ Division of Cardiology, Stanford University, Palo Alto, California
^## Case Western Reserve University, Cleveland, Ohio
^_*** University of Florence, Florence, Italy

View larger version (13K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Survival Analysis Kaplan-Meier estimates of time to death from any cause in the responder and the nonresponder groups.

View larger version (40K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Distribution of Tachyarrhythmias and Shock Therapies (A) Number of patients with episodes, and distribution of ventricular tachyarrhythmia episodes occurring during the 12 months after implant. (B) Trend of shock therapies delivered and patients with shock during the observation period. *p < 0.05 versus month 1, on the basis of chi-square analysis.

View larger version (17K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Primary and Secondary Prevention Patients Number of patients with episodes of ventricular arrhythmia during the 12 months after implant in primary and secondary prevention groups. *p < 0.05 versus month 1, on the basis of chi-square analysis.

View larger version (15K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Responder and Nonresponder Patients Number of patients with episodes of ventricular arrhythmia during the 12 months after implant in responder and nonresponder groups. *p < 0.05 versus month 1, on the basis of chi-square analysis.