Coenzyme Q10An Independent Predictor of Mortality in Chronic Heart Failure
Sarah L. Molyneux, PhD*,
Christopher M. Florkowski, MD*,*,
Peter M. George, MB, BS*,
Anna P. Pilbrow, PhD ,
Christopher M. Frampton, PhD,
Michael Lever, PhD* and
A. Mark Richards, MD, PhD
* Clinical Biochemistry Unit, Canterbury Health Laboratories, Christchurch, New Zealand
The Christchurch Cardioendocrine Research Group, Department of Medicine, University of Otago (Christchurch), Christchurch, New Zealand
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Figure 1 Receiver-Operator Characteristic Curve for CoQ10
The receiver-operator characteristic curve for plasma coenzyme Q10 (CoQ10) (red line) as a predictor of total mortality, showing the optimal cut-point of 0.73 µmol/l. The green line represents the zero discrimination line.
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Figure 2 Survival Related to CoQ10 Concentration and to CoQ10 and NT-proBNP 4-Way Split
(A) Survival related to the best predictive value of mortality for coenzyme Q10 (CoQ10) as determined from the receiver-operator characteristic (ROC) curve (0.73 µmol/l), showing values above (green) and below (blue) this cut-point. Log-rank p < 0.001 for the difference between groups. (B) Kaplan-Meier survival curve for patients with above- and below-median CoQ10 in combination with above- and below-median N-terminal peptide of B-type natriuretic peptide (NT-proBNP). Differences in survival among patient groups are indicated, except where nonsignificant. Medians: CoQ10 = 0.68 µmol/l; NT-proBNP = 238 pmol/l. Values below graphs indicate the number of subjects remaining in the study at each time point.
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