Plasma Interleukin-5 Levels Are Related to Antibodies Binding to Oxidized Low-Density Lipoprotein and to Decreased Subclinical Atherosclerosis
Maritta Sämpi, MS*,
Olavi Ukkola, MD, PhD*,
Markku Päivänsalo, MD, PhD ,
Y. Antero Kesäniemi, MD, PhD*,
Christoph J. Binder, MD, PhD and
Sohvi Hörkkö, MD, PhD ,*
* Department of Internal Medicine, Biocenter Oulu, Oulu, Finland
Department of Pharmacology and Toxicology, University of Oulu and Clinical Research Center of Oulu University Hospital, Oulu, Finland
Department of Radiology, University of Oulu, Oulu, Finland
Center for Molecular Medicine of the Austrian Academy of Sciences and Department of Medical and Chemical Laboratory Diagnostics, Medical University of Vienna, Vienna, Austria
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Figure 1 Plasma Antibody Titers to OxLDL by IL-5 Quartiles
Gender-adjusted IgM (A, B), total IgG (C, D), and IgG2 (E, F) antibodies binding to CuOx-LDL and MDA-LDL by IL-5 quartiles among the whole study group (N = 1,011). The data shown is mean (standard error of the mean). CuOx-LDL = copper oxidized low-density lipoprotein; Ig = immunoglobin; IL = interleukin; MDA-LDL = malondialdehyde-modified low-density lipoprotein; OxLDL = oxidized low-density lipoprotein; RU = relative units.
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Figure 2 Bifurcational Carotid Artery IMT by IL-5 Quartiles
Bifurcational carotid artery IMT by IL-5 quartiles among the whole study group (N = 1,011) before and after adjustments. Analyses were performed on the near-wall measurements (A, B), far-wall measurements (C, D), and mean IMT (E, F). Adjustments were made for age, gender, smoking, systolic blood pressure, low-density lipoprotein cholesterol, and body mass index. The data shown is mean (standard error of the mean). IMT = intima-media thickness; other abbreviations as in Figure 1.
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