Mortality Incidence and the Severity of Coronary Atherosclerosis Assessed by Computed Tomography Angiography
Matthew P. Ostrom, MD,
Ambarish Gopal, MD,
Naser Ahmadi, MD,
Khurram Nasir, MD, MPH,
Eric Yang, MD,
Ioannis Kakadiaris, PhD,
Ferdinand Flores, BS,
Song S. Mao, MD and
Matthew J. Budoff, MD*
Division of Cardiology, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California
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Figure 1 Noninvasive Angiography
Noninvasive angiography shows axial slice (right) and volume-rendered images (left). The volume-rendered image demonstrates a high-grade stenosis of both the left anterior descending artery (white arrow) and the right coronary artery (black arrow).
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Figure 2 Volume-Rendered CTA Image
A volume-rendered study demonstrating normal left anterior descending artery (L), diagonal (D), and circumflex (C) branches. CTA = computed tomography angiography.
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Figure 3 Event-Free Survival by CTA
Risk-adjusted event-free survival by computed tomography angiography (CTA)-diagnosed coronary artery disease (CAD) (left), and coronary artery calcium score (CACS) in the group with CTA-diagnosed nonobstructive CAD (right). Risk adjustment included the following variables: age, gender, hypertension, hypercholesterolemia, diabetes mellitus, smoking, family history of premature coronary heart disease (right), and CACS (left). The presence of CTA-diagnosed CAD increased the risk of all-cause mortality. In patients with CTA-diagnosed nonobstructive CAD, increasing CACS was associated with decreased survival.
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Figure 4 CTA Event-Free Survival
Risk-adjusted event-free survival by computed tomographic angiography (CTA)-diagnosed coronary artery disease (CAD) stratified by severity of disease and number of diseased coronary arteries. Risk adjustment included the following variables: age, gender, hypercholesterolemia, diabetes mellitus, smoking, hypertension, family history of premature coronary heart disease, and coronary artery calcium score. All-cause mortality increased significantly by increasing severity of CTA-diagnosed CAD and number of diseased coronary arteries.
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Figure 5 Receiver-Operator Characteristic Curves
Receiver-operator characteristic curves for 3 models created to assess the ability of a combination of clinical variables to predict all-cause mortality among symptomatic patients. CACS = coronary artery calcium score; CAD = coronary artery disease; CHD = coronary heart disease; CTA = computed tomography angiography.
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