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Azimilide Reduces Emergency Department Visits and Hospitalizations in Patients With an Implantable Cardioverter-Defibrillator in a Placebo-Controlled Clinical Trial

Paul Dorian, MD, FACC^_*,_*, Hussein R. Al-Khalidi, PhD, FAHA, Stefan H. Hohnloser, MD, FACC, Jose M. Brum, MD, MSc, Preston M. Dunnmon, MD, FACC, Craig M. Pratt, MD, FACC, Michael J. Holroyde, PhD, Peter Kowey, MD, FACC^|| on behalf of the SHIELD (SHock Inhibition Evaluation with AzimiLiDe) Investigators

^_* Division of Cardiology, St. Michael's Hospital/University of Toronto, Toronto, Ontario, Canada
Health Care Research Center, Procter & Gamble Pharmaceuticals, Cincinnati, Ohio
Department of Cardiology, Division of Electrophysiology, J.W. Goethe-University, Frankfurt, Germany
Methodist DeBakey Heart Center, Houston, Texas
^|| Division of Cardiovascular Diseases, Jefferson Medical College, Philadelphia, Pennsylvania

View larger version (17K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Kaplan-Meier Cumulative Incidence of Cardiac Arrhythmic-Related ED Visits and Hospitalizations AZ = azimilide; ED = emergency department; RRR = relative risk reduction.

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Cumulative Risk of Recurrent Cardiac-Related ED Visits or Hospitalizations Over Time by Treatment Group The slope of each curve represents the estimated rate of total cardiac-related ED visits or hospitalizations within each group. Abbreviations as in Figure 1.

View larger version (20K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Kaplan-Meier Cumulative Incidence of Cardiac Arrhythmic-Related ED Visits and Hospitalizations ATP = antitachycardia pacing; ED = emergency department; ICD = implantable cardioverter-defibrillator.