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Haptoglobin Genotype Is a Major Determinant of the Amount of Iron in the Human Atherosclerotic Plaque

Pedro R. Moreno, MD, FACC^_*, K. Raman Purushothaman, MD^_*, Meera Purushothaman, PhD^_*, Paul Muntner, PhD^_*, Nina S. Levy, PhD, Valentin Fuster, MD, PhD, FACC^_*, John T. Fallon, MD, PhD, Patrick A. Lento, MD, Aaron Winterstern, BS and Andrew P. Levy, MD, PhD, FACC^,_*

^_* Department of Medicine (Cardiology), Mount Sinai Medical Center, New York, New York
Department of Pathology, Mount Sinai Medical Center, New York, New York
Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Percentage of Plaques With Perl's Iron Stain by Hp Genotype and DM Status In patients with diabetes mellitus (DM), 24 of 52 plaques from 9 haptoglobin (Hp) 2-2 decedents compared with 6 of 51 plaques from 12 Hp 1-1 or 2-1 decedents demonstrated Perl's iron stain. In patients without DM, 11 of 41 plaques from 7 Hp 2-2 decedents compared with 5 of 45 plaques from 9 Hp 1-1 or 2-1 decedents demonstrated Perl's iron stain.