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J Am Coll Cardiol, 2008; 52:971-978, doi:10.1016/j.jacc.2008.06.019
© 2008 by the American College of Cardiology Foundation
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Hemoxygenase-1 in Cardiovascular Disease

Naglaa K. Idriss, MSc, Andrew D. Blann, PhD and Gregory Y.H. Lip, MD*

Haemostasis, Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, United Kingdom


Figure 1
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  		Figure 1 Schematic of Hemoxygenase-1–Catalyzed Biochemical Reactions

Hem released from red blood cells is enzymatically converted into carbon monoxide, bilirubin, and iron. The former is a vasodilator and promoter of angiogenesis. Bilirubin has potential antioxidant activity. Free ferrous iron has potential pro-oxidant activity, although this may be limited by its sequestration by ferritin.

 
 
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