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Common Genetic Polymorphisms and Haplotypes of Fibrinogen Alpha, Beta, and Gamma Chains Affect Fibrinogen Levels and the Response to Proinflammatory Stimulation in Myocardial Infarction Survivors

The AIRGENE Study

Bénédicte Jacquemin, MD, PhD^_*, Charalambos Antoniades, MD, PhD^,,_*, Fredrik Nyberg, MD, PhD^,||, Estel Plana, MSc^_*, Martina Müller, MSc, PhD^#,_**, Sonja Greven, MSc, PhD^#,,, Veikko Salomaa, MD, PhD, Jordi Sunyer, MD, PhD^_*,||||, Tom Bellander, MD, PhD, Alexandros-Georgios Chalamandaris, MSc^¶¶, Ricardo Pistelli, MD^##, Wolfgang Koenig, MD, PhD^¶ and Annette Peters, MSc, PhD^#

^_* Centre for Environmental Research, Municipal Institute of Medical Research, Barcelona, Spain
1st Cardiology Department, Athens University Medical School, Athens, Greece
Department of Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom
Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden
^|| AstraZeneca R&D Mölndal, Mölndal, Sweden
^¶ Department of Internal Medicine II Cardiology, University of Ulm Medical Centre, Ulm, Germany
^# Institute of Epidemiology, Research Units "Air Pollution Health Effects" and "Chronic Disease Epidemiology" German Research Center for Environmental Health (GmbH), Neuherberg, Germany
^_** LMU-IBE, Chair of Epidemiology, University of Munich, Neuherberg, Germany
LMU Institute of Statistics, University of Munich, Munich, Germany
Department of Biostatistics, John Hopkins University, Baltimore, Maryland
National Public Health Institute (KTL), Helsinki, Finland
^|||| Universitat Pompeu Fabra, Barcelona, Spain
^¶¶ Department of Hygiene and Epidemiology, Athens University Medical School, Athens, Greece
^## Catholic University, Rome, Italy

View larger version (26K): [in this window] [in a new window] [Download PPT slide]   Figure 1 LD Maps for FGA, FGB, and FGG Linkage disequilibrium (LD) maps for the 3 fibrinogen chain genes: fibrinogen chain alpha (FGA), beta (FGB), and gamma (FGG). D' (red) and r2 (blue) measures of LD are shown.