A Meta-Analysis of 17 Randomized Trials of a Percutaneous Coronary Intervention-Based Strategy in Patients With Stable Coronary Artery Disease
Albert Schömig, MD*,
Julinda Mehilli, MD,
Antoinette de Waha, MD,
Melchior Seyfarth, MD,
Jürgen Pache, MD and
Adnan Kastrati, MD
Deutsches Herzzentrum München, Technische Universität, Munich, Germany
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Figure 1 Odds Ratios for Mortality in Individual Trials Comparing the PCI-Based Strategy With Medical Treatment Strategy
Pooled odds ratios are also shown. PCI = percutaneous coronary intervention.
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Figure 2 Assessment of Publication Bias and Relationship Between Sample Size of the Trial and Treatment Effect
(A) Funnel plot for assessment of publication bias of trials comparing the PCI-based strategy with medical treatment strategy regarding mortality. The circles correspond to the treatment effects from individual trials, the red line shows the summary estimate, and the diagonal lines show the expected 95% confidence intervals around the summary estimate. Note that there is no evident asymmetry of the points in relation to the summary estimate that might indicate a relevant publication bias. (B) Relationship between sample size of the trial and treatment effect regarding mortality. Both treatment effect and sample size are shown on a logarithmic scale. Note the lack of an evident relationship between sample size and observed treatment effect. PCI = percutaneous coronary intervention.
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Figure 3 Follow-Up Interval and Odds Ratios for Mortality for PCI Versus Medical Treatment
Odds ratios are shown in pairs, from the random effects model on the left and from the fixed effects model on the right. FU = follow-up; PCI = percutaneous coronary intervention.
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Figure 4 Odds Ratios for Mortality for PCI Versus Medical Treatment in Various Subsets
Odds ratios are shown in pairs, from the random effects (upper line) and from the fixed effects model (lower line). CABG = coronary artery bypass graft; MI = myocardial infarction; PCI = percutaneous coronary intervention.
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Figure 5 Odds Ratios for Cardiac Death in Individual Trials Comparing the PCI-Based Strategy With Medical Treatment Strategy
Pooled odds ratios are also shown. PCI = percutaneous coronary intervention.
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Figure 6 Odds Ratios for Nonfatal Myocardial Infarction in Individual Trials Comparing the PCI-Based Strategy With Medical Treatment Strategy
Pooled odds ratios are also shown. MI = nonfatal myocardial infarction; PCI = percutaneous coronary intervention.
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