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Aortic Atherosclerosis, Hypercoagulability, and Stroke

The APRIS (Aortic Plaque and Risk of Ischemic Stroke) Study

Marco R. Di Tullio, MD^_*,_*, Shunichi Homma, MD, FACC^_*, Zhezhen Jin, PhD and Ralph L. Sacco, MD

^_* Department of Medicine, Columbia University Medical Center, New York, New York
Department of Biostatistics, Columbia University Medical Center, New York, New York
Departments of Neurology, Epidemiology, and Human Genetics, University of Miami, Miami, Florida

View larger version (150K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Example of Large, Complex Plaque in the Aortic Arch An ulceration and 2 faintly echogenic superimposed thrombi are visualized (arrow).

View larger version (8K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Kaplan-Meier Event-Free Curves in Stroke Patients Data are presented according to arch plaque thickness and prothrombin fragment F 1.2 levels. Blue lines = large plaque and F1.2 < median (n = 24, event = 5); red lines = large plaque and F1.2 median (n = 34, event = 15).