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Anemia and Mortality in Heart Failure Patients

A Systematic Review and Meta-Analysis

Hessel F. Groenveld, MD^_*, James L. Januzzi, MD, FACC, Kevin Damman, MD^_*, Jan van Wijngaarden, MD, PhD, Hans L. Hillege, MD, PhD^_*, Dirk J. van Veldhuisen, MD, PhD, FACC^_* and Peter van der Meer, MD, PhD^,_*

^_* Department of Cardiology, University Medical Center Groningen, Groningen, the Netherlands
Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Department of Cardiology, Deventer Hospital, Deventer, the Netherlands

View larger version (18K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Flow Chart for Study Selection CHF = chronic heart failure; Hb = hemoglobin.

View larger version (30K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Risk of All-Cause Mortality of Anemic Versus Nonanemic CHF Patients CHF = chronic heart failure. CI = confidence interval.

View larger version (9K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Funnel Plot for Publication Bias OR = odds ratio.

View larger version (16K): [in this window] [in a new window] [Download PPT slide]   Figure 4 Relationship Between Baseline Hemoglobin and Annual Mortality The area of each circle is proportional to the sample size in each cohort. The center line shows the estimated mortality risk per year of lower baseline Hb values on a continuous scale. The dotted lines represent the 95% confidence intervals.