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Safety and Efficacy of Bivalirudin With and Without Glycoprotein IIb/IIIa Inhibitors in Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention

1-Year Results From the ACUITY (Acute Catheterization and Urgent Intervention Triage strategY) Trial

Harvey D. White, DSc, FACC^_*,_*, E. Magnus Ohman, MD, FACC, A. Michael Lincoff, MD, FACC, Michel E. Bertrand, MD, FACC, Antonio Colombo, MD, FACC^||, Brent T. McLaurin, MD, FACC^¶, David A. Cox, MD, FACC^#, Stuart J. Pocock, PhD^_**, James A. Ware, PhD, Steven V. Manoukian, MD, FACC, Alexandra J. Lansky, MD, FACC, Roxana Mehran, MD, FACC, Jeffrey W. Moses, MD, FACC and Gregg W. Stone, MD, FACC

^_* Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand
Duke University Medical Center, Durham, North Carolina
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio
Lille Heart Institute, Lille, France
^|| EMO Centro Cuore Columbus, San Raffaele Scientific Institute, Milan, Italy
^¶ University of South Carolina School of Medicine, Columbia, South Carolina
^# Mid Carolina Cardiology, Charlotte and Durham, North Carolina
^_** London School of Hygiene and Tropical Medicine, London, United Kingdom
Harvard School of Public Health, Boston, Massachusetts
Sarah Cannon Research Institute and Centennial Heart Center, Nashville, Tennessee
Columbia University Medical Center and the Cardiovascular Research Foundation, New York, New York

View larger version (12K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Enrollment and Randomization of the ACUITY Trial ACS = acute coronary syndromes; CABG = coronary artery bypass graft surgery; GP = glycoprotein; PCI = percutaneous coronary intervention; UFH = unfractionated heparin.

View larger version (40K): [in this window] [in a new window] [Download PPT slide]   Figure 3 Mortality and Composite Ischemia in Subgroups Comparison of mortality (A) and composite ischemia (B) in patients randomly assigned to UFH or enoxaparin plus a GP IIb/IIIa inhibitor versus bivalirudin monotherapy, displayed as risk ratio (RR) (black boxes) with 95% CI (horizontal lines). CI = confidence interval; CrCl = creatinine clearance; pint = value for the interaction between the variable and the relative treatment effect; TIMI = Thrombolysis In Myocardial Infarction; other abbreviations as in Figure 1.