Relationship Between Biomarkers of Oxidized Low-Density Lipoprotein, Statin Therapy, Quantitative Coronary Angiography, and Atheroma VolumeObservations From the REVERSAL (Reversal of Atherosclerosis with Aggressive Lipid Lowering) Study
Seung Hyuk Choi, MD*, ,
Andrew Chae, BS,
Elizabeth Miller, BS,
Michael Messig, PhD ,
Fady Ntanios, PhD,
Anthony N. DeMaria, MD, MACC,
Steven E. Nissen, MD, FACC*,
Joseph L. Witztum, MD and
Sotirios Tsimikas, MD, FACC,*
* Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
Pfizer Inc, New York, New York
 Cleveland Clinic Foundation, Cleveland, Ohio
University of California–San Diego, San Diego, California.
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Figure 1 Statins and Lipid Parameters
The influence of statin therapy on lipid parameters. ApoB = apolipoprotein B-100; CI = confidence interval; HDL-C = high-density lipoprotein cholesterol; LDL-C = low-density lipoprotein cholesterol.
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Figure 2 Statins and Biomarkers
The influence of statin therapy on plasma oxidized low-density lipoprotein (OxLDL) biomarkers and high sensitivity C-reactive protein (CRP). apoB-IC = apolipoprotein B-100 immune complexes; CI = confidence interval; IC/apoB = immune complexes per apolipoprotein B-100; Ig = immunoglobin; Lp(a) = lipoprotein (a); MDA = malondialdehyde; MDA/apoB = malondialdehyde epitopes per apolipoprotein B-100; OxPL/apoB = oxidized phospholipid epitopes per apolipoprotein B-100.
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Figure 3 Atheroma Volume and Oxidation-Specific Epitopes
Locally weighted scatter plots showing the relationship between the percentage change in atheroma volume and the percentage change in OxPL/apoB, MDA/apoB, and Lp(a) in the 214 patients. In each plot, the solid line represents the point estimates and the dashed lines the 95% confidence intervals. Abbreviations as in Figure 2.
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Figure 4 Relationship of Lp(a) to Oxidation-Specific Epitopes
Spearman correlations between baseline levels of Lp(a) with OxPL/apoB and Lp(a) and MDA/apoB. Dashed lines represent the 95% confidence interval. RLU = relative light units; other abbreviations as in Figure 2.
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