Randomized Comparison of Distal Protection Versus Conventional Treatment in Primary Percutaneous Coronary InterventionThe Drug Elution and Distal Protection in ST-Elevation Myocardial Infarction (DEDICATION) Trial
Henning Kelbæk, MD*,
Christian J. Terkelsen, MD ,
Steffen Helqvist, MD*,
Jens F. Lassen, MD,
Peter Clemmensen, MD*,
Lene Kløvgaard, RN*,
Anne Kaltoft, MD,
Thomas Engstrøm, MD*,
Hans E. Bøtker, MD,
Kari Saunamäki, MD*,
Lars R. Krusell, MD,
Erik Jørgensen, MD*,
Hans-Henrik T. Hansen, MD*,
Evald H. Christiansen, MD,
Jan Ravkilde, MD,
Lars Køber, MD*,
Klaus F. Kofoed, MD* and
Leif Thuesen, MD,*
* Department of Cardiology and Cardiac Catheterization Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
Department of Cardiology, Aarhus University Hospital, Skejby, Denmark.
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Figure 1 Complete ST-Segment Resolution
Cumulative frequency curves of patients achieving  70% resolution of the ST-segment 90 min after primary percutaneous coronary intervention show a small, insignificant difference in the 2 groups receiving distal protection and conventional treatment.
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Figure 2 Cardiac Biomarkers and WMI
Maximal levels of cardiac biomarkers and echocardiographic determination of left ventricular wall motion index (WMI) after primary percutaneous coronary intervention in the 2 groups receiving distal protection and conventional treatment. CK-MB = creatine kinase-MB.
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Figure 4 Subgroup Analyses for the Primary End Point
Subgroup analyses with regard to complete ST-segment resolution. BMS = bare-metal stent; CX = circumflex coronary artery; DES = drug-eluting stent; DM = diabetes mellitus; LAD = left anterior descending coronary artery; RCA = right coronary artery; TIMI = Thrombolysis In Myocardial Infarction.
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