Effects of Ramipril on Endothelial Function and the Expression of Proinflammatory Cytokines and Adhesion Molecules in Young Normotensive Subjects With Successfully Repaired Coarctation of AortaA Randomized Cross-Over Study
Stella Brili, MD, FACC1,
Dimitris Tousoulis, MD, PhD, FACC1,*,
Charalambos Antoniades, MD,
Carmen Vasiliadou, MSc,
Maria Karali, MD,
Nikos Papageorgiou, MD,
Nikos Ioakeimidis, MD,
Kyriakoula Marinou, MD,
Elli Stefanadi, MD and
Christodoulos Stefanadis, MD, FACC, FESC
First Cardiology Department, Athens University Medical School, Hippokration Hospital, Athens, Greece.
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Figure 2 Effects of Ramipril on Forearm Hyperemic Responses
Treatment with ramipril had no effect on resting forearm blood flow (FBF) (A), whereas it significantly improved maximum hyperemic FBF (B) and reactive hyperemia (C). Ramipril had no effect on nitrate-induced vasodilation in the forearm (D to F). *p < 0.01 versus before treatment. NTG = forearm vasodilator response to nitrate.
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Figure 3 Effects of Ramipril on sCD40L, IL-1b, and IL-6
Treatment with ramipril induced a borderline (p = 0.055) decrease of interleukin (IL)-1b (A) and a significant decrease of IL-6 (B) and soluble CD40 ligand (sCD40L) (C) in normotensive subjects with successfully repaired coarctation of the aorta. *p < 0.05; **p < 0.01 versus before treatment.
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Figure 4 Effect of Ramipril on sVCAM-1 and CRP Levels
Treatment with ramipril induced a significant decrease of circulating soluble vascular cell adhesion molecule (sVCAM)-1 (A). However, serum levels of C-reactive protein (CRP) remained unchanged after 4 weeks’ treatment with ramipril (B). *p < 0.01 versus before treatment.
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