Impact of Triglyceride Levels Beyond Low-Density Lipoprotein Cholesterol After Acute Coronary Syndrome in the PROVE IT-TIMI 22 Trial
Michael Miller, MD, FACC*,1,*,
Christopher P. Cannon, MD, FACC ,2,
Sabina A. Murphy, MPH,
Jie Qin, MS,
Kausik K. Ray, MD, MRCP ,3,
Eugene Braunwald, MD, MACC,4 for the PROVE IT-TIMI 22 Investigators
* University of Maryland Medical Center, Baltimore, Maryland
TIMI Study Group, Brigham and Women’s Hospital, Boston, Massachusetts
University of Cambridge, Cambridge, United Kingdom.
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Figure 1 Kaplan-Meier Curves
Estimates of death, myocardial infarction, and recurrent acute coronary syndrome between 30 days and 2 years of follow-up based on (A) achieved low-density lipoprotein cholesterol (LDL-C) <70 mg/dl and (B) triglycerides (TG) <150 mg/dl. The 95% confidence intervals are in parentheses. HR = hazard ratio.
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Figure 2 Risk of Recurrent Events Using Selected Cut-Points of LDL-C and TG
Event rate and adjusted hazard of death, myocardial infarction (MI), and recurrent acute coronary syndrome (ACS) between 30 days and 2 years of follow-up with achieved LDL-C and TG based on the designated cut-points of 70 mg/dl and 150 mg/dl, respectively. The referent (Ref) group is LDL-C  70 mg/dl and TG 150 mg/dl. This model is adjusted for age, gender, low HDL-C, smoking, hypertension, obesity, diabetes, prior statin therapy, prior ACS, peripheral vascular disease, and treatment effect. The 95% confidence intervals are located below the HRs. Abbreviations as in Figure 1.
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