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J Am Coll Cardiol, 2008; 51:701-707, doi:10.1016/j.jacc.2007.10.034
© 2008 by the American College of Cardiology Foundation
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The Problem With Composite End Points in Cardiovascular Studies

The Story of Major Adverse Cardiac Events and Percutaneous Coronary Intervention

Kevin E. Kip, PhD*,*, Kim Hollabaugh, RN, MSN{dagger}, Oscar C. Marroquin, MD, FACC{ddagger} and David O. Williams, MD, FACC§

* College of Nursing, University of South Florida, Tampa, Florida
{dagger} School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania
{ddagger} Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania
§ Department of Cardiology, Rhode Island Hospital, Providence, Rhode Island.


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  		Figure 1 Adjusted Hazard Ratios for Different MACE Definitions

Adjusted hazard ratios of different definitions of major adverse cardiac events (MACE) comparing acute myocardial infarction (MI) versus nonacute MI patients (top) and patients with multilesion versus single-lesion percutaneous coronary intervention (bottom). Filled center circles depict the adjusted hazard ratios, filled circles at the left and right ends depict the lower and upper 95% confidence limits. Revasc = revascularization; ST = stent thrombosis; TVR = target vessel revascularization.

 
 
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