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J Am Coll Cardiol, 2008; 51:698-700, doi:10.1016/j.jacc.2007.10.042
© 2008 by the American College of Cardiology Foundation
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Percutaneous Coronary Intervention Pharmacology

From a Triangle to a Square*

Harold L. Dauerman, MD, FACC1,*

University of Vermont College of Medicine, Burlington, Vermont.


Figure 1
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Figure 1 PCI Pharmacology Trials: From the Triple to the Quadruple End Point

The current meta-analysis suggests that the primary end point of percutaneous coronary intervention (PCI) pharmacology trials needs revision. Instead of a triple end point—death, asymptomatic creatine kinase-myocardial band (CK-MB)/symptomatic myocardial infarction (MI), and target vessel revascularization (TVR)—future trials might focus on the quadruple end point, which includes the mortality risk of major bleeding. GPI = glycoprotein IIb/IIIa inhibitor.

 




 
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