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High-Density Lipoprotein Cholesterol, High-Density Lipoprotein Particle Size, and Apolipoprotein A-I: Significance for Cardiovascular Risk

The IDEAL and EPIC-Norfolk Studies

Wim A. van der Steeg, MD^_*, Ingar Holme, PhD, S. Matthijs Boekholdt, MD, PhD^_*, Mogens Lytken Larsen, MD, DMSc, Christina Lindahl, MD, Erik S.G. Stroes, MD, PhD^_*, Matti J. Tikkanen, MD, PhD^||, Nicholas J. Wareham, MBBS, PhD^¶, Ole Faergeman, MD, DMSc, Anders G. Olsson, MD, PhD^#, Terje R. Pedersen, MD, PhD, Kay-Tee Khaw, MBBChir^_** and John J.P. Kastelein, MD, PhD^_*,_*

^_* Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Center for Preventive Medicine, Ullevål University Hospital, Oslo, Norway
Department of Medicine-Cardiology A, Århus, Denmark
Pfizer Sweden, Täby, Sweden
^|| Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
^¶ Medical Research Council Epidemiology Unit, Cambridge, United Kingdom
^# Department of Internal Medicine, University Hospital, Linköping, Sweden
^_** Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, United Kingdom.

View larger version (12K): [in this window] [in a new window] [Download PPT slide]   Figure 1 Risk Estimates for Subgroups of HDL-C (IDEAL) and NMR-Measured HDL Particle Size (EPIC-Norfolk) All risk estimates were calculated taking into account a basic set of parameters, including age, gender, smoking (IDEAL) (A), and body mass index and alcohol consumption (U/week) (EPIC-Norfolk) (B). apo = apolipoprotein; HDL = high-density lipoprotein; HDL-C = high-density lipoprotein cholesterol; MCE = major coronary event; NMR = nuclear magnetic resonance.

View larger version (11K): [in this window] [in a new window] [Download PPT slide]   Figure 2 Risk Estimates for Subgroups of apoA-I in IDEAL and EPIC-Norfolk All risk estimates were calculated taking into account a basic set of parameters, including age, gender, smoking (IDEAL) (A), and body mass index and alcohol consumption (U/week) (EPIC-Norfolk) (B and C). Abbreviations as in Figure 1.