Cardiac Magnetic Resonance Imaging Study for Quantification of Infarct Size Comparing Directly Serial Versus Single Time-Point Measurements of Cardiac Troponin T
Evangelos Giannitsis, MD*,1,4,
Henning Steen, MD*,4,
Kerstin Kurz, MD*,
Boris Ivandic, MD*,
Anke C. Simon, MD*,
Simon Futterer, MD*,
Christian Schild, MD*,
Peter Isfort, MD*,
Allan S. Jaffe, MD, FACC ,3,* and
Hugo A. Katus, MD, FACC*,2
* Abteilung Innere Medizin III, Medizinische Klinik, Universitätsklinikum Heidelberg, Heidelberg, Germany
Mayo Clinic and Mayo Medical School, Rochester, Minnesota.
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Figure 1 Correlation Coefficients
Plots showing correlation by Spearman rank correlation between contrast-enhanced magnetic resonance imaging infarct mass and cardiac troponin T (cTnT) concentrations during the entire sampling period (A), for any single-point (B to E), for peak cTnT (F), and cumulative cTnT over 96 h (cTnT area under the curve [AUC]) (G). Correlation coefficients are displayed with corresponding 95% confidence intervals. The z-statistics show no statistical difference across any single-point cTnT between Day (D) 1 and Day 4.
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Figure 2 ROC Curve Analysis for cTnT D4, cTnT Peak, and AUC cTnT for Prediction of Infarct Mass Above Median
Receiver-operator characteristic (ROC) curve analysis for cTnT D4, cTnT peak, and cTnT AUC for prediction of infarct mass above median demonstrates a comparable performance of best single-point versus serial measurements. Display of ROC analysis include optimized cutoff concentrations and AUC with corresponding 95% confidence intervals. Other abbreviations as in Figure 1.
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