Ethanol Abolishes Ischemic Preconditioning in Humans
Giampaolo Niccoli, MD, PhD*,
Luca Altamura, MD,
Alessandro Fabretti, MD,
Gaetano A. Lanza, MD,
Luigi M. Biasucci, MD,
Antonio G. Rebuzzi, MD,
Antonio Maria Leone, MD,
Italo Porto, MD, PhD,
Francesco Burzotta, MD, PhD,
Carlo Trani, MD and
Filippo Crea, MD, FACC
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy.
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Figure 1 Plots of Individual Values of ST-Segment Shift on the IC-ECG During the First and Second Inflation in the 2 Groups of Patients
In gin-treated patients (left), ST-segment changes during the second inflation were significantly greater than those during the first inflation (p = 0.03). Conversely, in placebo-treated patients (right), ST-segment changes during the second inflation were significantly less than those during the first inflation (p = 0.005). IC-ECG = intracoronary electrocardiogram.
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Figure 2 Plots of Individual Values of Cardiac Pain Severity at the End of the First and Second Inflation in the 2 Groups of Patients
In gin-treated patients (left), cardiac pain severity at the end of the second inflation was similar at that at the end of the first inflation (p = 0.14). In contrast, in placebo-treated patients (right), cardiac pain severity at the end of the second inflation was significantly less than that at the end of the first inflation (p = 0.0001).
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Figure 3 Ethanol Blood Levels of the Last 5 Gin-Treated Patients Before Coronary Intervention
In all patients, ethanol blood levels were high at the beginning of the coronary angioplasty procedure. The correlation between ethanol levels and ST-segment shift between the first and the second inflation was significant (p = 0.037).  = difference of ST-segment shift between second and first inflation; solid bars = second inflation; open bars = first inflation; Pt = patients.
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